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A backbone amide protecting group for overcoming difficult sequences and suppressing aspartimide formation
A backbone amide bond protecting group, 2‐hydroxy‐4‐methoxy‐5‐nitrobenzyl (Hmnb), improved the synthesis of aggregation and aspartimide‐prone peptides. Introduction of Hmnb is automated and carried out during peptide assembly by addition of 4‐methoxy‐5‐nitrosalicylaldehyde to the peptidyl‐resin and...
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| Publicado no: | J Pept Sci |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5074248/ https://ncbi.nlm.nih.gov/pubmed/27086749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psc.2877 |
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