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A backbone amide protecting group for overcoming difficult sequences and suppressing aspartimide formation
A backbone amide bond protecting group, 2‐hydroxy‐4‐methoxy‐5‐nitrobenzyl (Hmnb), improved the synthesis of aggregation and aspartimide‐prone peptides. Introduction of Hmnb is automated and carried out during peptide assembly by addition of 4‐methoxy‐5‐nitrosalicylaldehyde to the peptidyl‐resin and...
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| Pubblicato in: | J Pept Sci |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5074248/ https://ncbi.nlm.nih.gov/pubmed/27086749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psc.2877 |
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