An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4

The human HSV-1 and -2 are common pathogens of human diseases. Both host and viral factors are involved in HSV lytic infection, although detailed mechanisms remain elusive. By screening a chemical library of epigenetic regulation, we identified bromodomain-containing protein 4 (BRD4) as a critical p...

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Publicat a:PLoS Pathog
Autors principals: Ren, Ke, Zhang, Wei, Chen, Xiaoqing, Ma, Yingyu, Dai, Yue, Fan, Yimei, Hou, Yayi, Tan, Ren Xiang, Li, Erguang
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072739/
https://ncbi.nlm.nih.gov/pubmed/27764245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005950
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