Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

We tested the hypothesis that angiotensin II-induced hypertension is associated with an increase in vascular .O2- production, and characterized the oxidase involved in this process. Infusion of angiotensin II (0.7 mg/kg per d) increased systolic blood pressure and doubled vascular .O2- production (a...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Rajagopalan, S, Kurz, S, Münzel, T, Tarpey, M, Freeman, B A, Griendling, K K, Harrison, D G
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 1996
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507261/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8621776/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118623
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