Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

We tested the hypothesis that angiotensin II-induced hypertension is associated with an increase in vascular .O2- production, and characterized the oxidase involved in this process. Infusion of angiotensin II (0.7 mg/kg per d) increased systolic blood pressure and doubled vascular .O2- production (a...

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Bibliographic Details
Main Authors: Rajagopalan, S, Kurz, S, Münzel, T, Tarpey, M, Freeman, B A, Griendling, K K, Harrison, D G
Format: Artigo
Language:Inglês
Published: 1996
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC507261/
https://ncbi.nlm.nih.gov/pubmed/8621776
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