Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug.

Hydralazine has been shown to reduce mortality in patients with congestive heart failure when given concomitantly with isosorbide dinitrate. Recently, we demonstrated that nitrate tolerance is in part due to enhanced vascular superoxide .O2- production. We sought to determine mechanisms whereby hydr...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Münzel, T, Kurz, S, Rajagopalan, S, Thoenes, M, Berrington, W R, Thompson, J A, Freeman, B A, Harrison, D G
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1996
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC507574/
https://ncbi.nlm.nih.gov/pubmed/8823313
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