Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug.

Hydralazine has been shown to reduce mortality in patients with congestive heart failure when given concomitantly with isosorbide dinitrate. Recently, we demonstrated that nitrate tolerance is in part due to enhanced vascular superoxide .O2- production. We sought to determine mechanisms whereby hydr...

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Detalhes bibliográficos
Main Authors: Münzel, T, Kurz, S, Rajagopalan, S, Thoenes, M, Berrington, W R, Thompson, J A, Freeman, B A, Harrison, D G
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC507574/
https://ncbi.nlm.nih.gov/pubmed/8823313
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