Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug.

Hydralazine has been shown to reduce mortality in patients with congestive heart failure when given concomitantly with isosorbide dinitrate. Recently, we demonstrated that nitrate tolerance is in part due to enhanced vascular superoxide .O2- production. We sought to determine mechanisms whereby hydr...

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Библиографические подробности
Главные авторы: Münzel, T, Kurz, S, Rajagopalan, S, Thoenes, M, Berrington, W R, Thompson, J A, Freeman, B A, Harrison, D G
Формат: Artigo
Язык:Inglês
Опубликовано: 1996
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC507574/
https://ncbi.nlm.nih.gov/pubmed/8823313
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