Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug.

Hydralazine has been shown to reduce mortality in patients with congestive heart failure when given concomitantly with isosorbide dinitrate. Recently, we demonstrated that nitrate tolerance is in part due to enhanced vascular superoxide .O2- production. We sought to determine mechanisms whereby hydr...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Münzel, T, Kurz, S, Rajagopalan, S, Thoenes, M, Berrington, W R, Thompson, J A, Freeman, B A, Harrison, D G
Format: Artigo
Langue:Inglês
Publié: 1996
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC507574/
https://ncbi.nlm.nih.gov/pubmed/8823313
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