Transcription of the tumor necrosis factor alpha gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FK506 in human B cells.

The human tumor necrosis factor alpha (TNF-alpha) gene encodes a cytokine whose activities have been implicated in many immunopathological processes, including the activation and differentiation of lymphocytes. Originally identified as a monocyte factor, our studies and those of others have demonstr...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Goldfeld, A E, Flemington, E K, Boussiotis, V A, Theodos, C M, Titus, R G, Strominger, J L, Speck, S H
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1992
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50726/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1281550/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.24.12198
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