Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location.

The immunosuppressants cyclosporin A (CsA) and FK506 appear to block T-cell function by inhibiting the calcium-regulated phosphatase calcineurin. While multiple distinct intracellular receptors for these drugs (cyclophilins and FKBPs, collectively immunophilins) have been characterized, the function...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Bram, R J, Hung, D T, Martin, P K, Schreiber, S L, Crabtree, G R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360102/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7687744/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.8.4760-4769.1993
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