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A Two-Metal-Ion-Mediated Conformational Switching Pathway for HDV Ribozyme Activation

RNA enzymes serve as a potentially powerful platform from which to design catalysts and engineer new biotechnology. A fundamental understanding of these systems provides insight to guide design. The hepatitis delta virus ribozyme (HDVr) is a small, self-cleaving RNA motif widely distributed in natur...

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Detalles Bibliográficos
Publicado en:ACS Catal
Main Authors: Lee, Tai-Sung, Radak, Brian K., Harris, Michael E., York, Darrin M.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072530/
https://ncbi.nlm.nih.gov/pubmed/27774349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.5b02158
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