PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage

Nuclear factor kappa B (NF-κB) promotes cell survival in response to genotoxic stress by inducing the expression of anti-apoptotic proteins including Bcl-xL, which protects mitochondria from stress-induced mitochondrial outer membrane permeabilization (MOMP). Here we show that the multifunctional so...

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Bibliographic Details
Published in:Cell Death Differ
Main Authors: Barroso-González, J, Auclair, S, Luan, S, Thomas, L, Atkins, K M, Aslan, J E, Thomas, L L, Zhao, J, Zhao, Y, Thomas, G
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072422/
https://ncbi.nlm.nih.gov/pubmed/26943323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.23
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