Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease.

Pathologic water loss from sickle erythrocytes concentrates the abnormal hemoglobin and promotes sickling. The Ca2+-activated K+ channel (Gardos channel) contributes to this deleterious dehydration in vitro, and blockade of K+ and water loss via this channel could be a potential therapy in vivo. We...

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Bibliographische Detailangaben
Hauptverfasser: Brugnara, C, Gee, B, Armsby, C C, Kurth, S, Sakamoto, M, Rifai, N, Alper, S L, Platt, O S
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1996
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC507175/
https://ncbi.nlm.nih.gov/pubmed/8636434
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