Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease.

Antzeko izenburuak

• Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives.
  nork: Brugnara, C, et al.
  Argitaratua: (1993)
• Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease.
  nork: De Franceschi, L, et al.
  Argitaratua: (1997)
• Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease.
  nork: Shmukler, Boris E., et al.
  Argitaratua: (2019)
• Treatment with oral clotrimazole blocks Ca(2+)-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease.
  nork: De Franceschi, L, et al.
  Argitaratua: (1994)
• Red blood cell Gardos channel (KCNN4): the essential determinant of erythrocyte dehydration in hereditary xerocytosis
  nork: Rapetti-Mauss, Raphaël, et al.
  Argitaratua: (2017)