Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease.

Pathologic water loss from sickle erythrocytes concentrates the abnormal hemoglobin and promotes sickling. The Ca2+-activated K+ channel (Gardos channel) contributes to this deleterious dehydration in vitro, and blockade of K+ and water loss via this channel could be a potential therapy in vivo. We...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Brugnara, C, Gee, B, Armsby, C C, Kurth, S, Sakamoto, M, Rifai, N, Alper, S L, Platt, O S
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507175/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8636434/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118537
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