Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease.
Pathologic water loss from sickle erythrocytes concentrates the abnormal hemoglobin and promotes sickling. The Ca2+-activated K+ channel (Gardos channel) contributes to this deleterious dehydration in vitro, and blockade of K+ and water loss via this channel could be a potential therapy in vivo. We...
Bewaard in:
| Gepubliceerd in: | J Clin Invest |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Clinical Investigation
1996
|
| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507175/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8636434/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118537 |
| Tags: |
Geen labels, Wees de eerste die dit record labelt!
|