Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease.

Pathologic water loss from sickle erythrocytes concentrates the abnormal hemoglobin and promotes sickling. The Ca2+-activated K+ channel (Gardos channel) contributes to this deleterious dehydration in vitro, and blockade of K+ and water loss via this channel could be a potential therapy in vivo. We...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Brugnara, C, Gee, B, Armsby, C C, Kurth, S, Sakamoto, M, Rifai, N, Alper, S L, Platt, O S
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 1996
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507175/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8636434/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118537
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