Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis.

CTLA4Ig, a fusion protein that blocks CD28-B7 costimulation, was studied in a LEW to F344 rat model of chronic cardiac rejection. In rats treated with a single dose of CTLA4Ig (0.5 mg intraperitoneally) 2 d after transplantation, allografts survived significantly longer ( > 70 d in 64%) than in u...

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Detaylı Bibliyografya
Asıl Yazarlar: Russell, M E, Hancock, W W, Akalin, E, Wallace, A F, Glysing-Jensen, T, Willett, T A, Sayegh, M H
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1996
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC507122/
https://ncbi.nlm.nih.gov/pubmed/8609241
Etiketler: Etiketle
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