Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection.

Blocking CD28-B7 T-cell costimulation by systemic administration of CTLA4Ig, a fusion protein which binds B7 molecules on the surface of antigen-presenting cells, prevents rejection and induces tolerance in experimental acute allograft rejection models. We tested the effect of CTLA4Ig therapy on the...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Azuma, H, Chandraker, A, Nadeau, K, Hancock, W W, Carpenter, C B, Tilney, N L, Sayegh, M H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38010/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8901600/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.22.12439
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