Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection.

Blocking CD28-B7 T-cell costimulation by systemic administration of CTLA4Ig, a fusion protein which binds B7 molecules on the surface of antigen-presenting cells, prevents rejection and induces tolerance in experimental acute allograft rejection models. We tested the effect of CTLA4Ig therapy on the...

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Autori principali: Azuma, H, Chandraker, A, Nadeau, K, Hancock, W W, Carpenter, C B, Tilney, N L, Sayegh, M H
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC38010/
https://ncbi.nlm.nih.gov/pubmed/8901600
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