Pitfalls of improperly procured adjacent non-neoplastic tissue for somatic mutation analysis using next-generation sequencing

BACKGROUND: The rapid adoption of next-generation sequencing provides an efficient system for detecting somatic alterations in neoplasms. The detection of such alterations requires a matched non-neoplastic sample for adequate filtering of non-somatic events such as germline polymorphisms. Non-neopla...

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Enregistré dans:
Détails bibliographiques
Publié dans:BMC Med Genomics
Auteurs principaux: Wei, Lei, Papanicolau-Sengos, Antonios, Liu, Song, Wang, Jianmin, Conroy, Jeffrey M., Glenn, Sean T., Brese, Elizabeth, Hu, Qiang, Miles, Kiersten Marie, Burgher, Blake, Qin, Maochun, Head, Karen, Omilian, Angela R., Bshara, Wiam, Krolewski, John, Trump, Donald L., Johnson, Candace S., Morrison, Carl D.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070097/
https://ncbi.nlm.nih.gov/pubmed/27756300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-016-0226-1
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