Pitfalls of improperly procured adjacent non-neoplastic tissue for somatic mutation analysis using next-generation sequencing

BACKGROUND: The rapid adoption of next-generation sequencing provides an efficient system for detecting somatic alterations in neoplasms. The detection of such alterations requires a matched non-neoplastic sample for adequate filtering of non-somatic events such as germline polymorphisms. Non-neopla...

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Pubblicato in:BMC Med Genomics
Autori principali: Wei, Lei, Papanicolau-Sengos, Antonios, Liu, Song, Wang, Jianmin, Conroy, Jeffrey M., Glenn, Sean T., Brese, Elizabeth, Hu, Qiang, Miles, Kiersten Marie, Burgher, Blake, Qin, Maochun, Head, Karen, Omilian, Angela R., Bshara, Wiam, Krolewski, John, Trump, Donald L., Johnson, Candace S., Morrison, Carl D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070097/
https://ncbi.nlm.nih.gov/pubmed/27756300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-016-0226-1
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