Pitfalls of improperly procured adjacent non-neoplastic tissue for somatic mutation analysis using next-generation sequencing

BACKGROUND: The rapid adoption of next-generation sequencing provides an efficient system for detecting somatic alterations in neoplasms. The detection of such alterations requires a matched non-neoplastic sample for adequate filtering of non-somatic events such as germline polymorphisms. Non-neopla...

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Udgivet i:BMC Med Genomics
Main Authors: Wei, Lei, Papanicolau-Sengos, Antonios, Liu, Song, Wang, Jianmin, Conroy, Jeffrey M., Glenn, Sean T., Brese, Elizabeth, Hu, Qiang, Miles, Kiersten Marie, Burgher, Blake, Qin, Maochun, Head, Karen, Omilian, Angela R., Bshara, Wiam, Krolewski, John, Trump, Donald L., Johnson, Candace S., Morrison, Carl D.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070097/
https://ncbi.nlm.nih.gov/pubmed/27756300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-016-0226-1
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