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Disruption of the SH2-B Gene Causes Age-Dependent Insulin Resistance and Glucose Intolerance
Insulin regulates glucose homeostasis by binding and activating the insulin receptor, and defects in insulin responses (insulin resistance) induce type 2 diabetes. SH2-B, an Src homology 2 (SH2) and pleckstrin homology domain-containing adaptor protein, binds via its SH2 domain to insulin receptor i...
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| Veröffentlicht in: | Mol Cell Biol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC506995/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15314154/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.17.7435-7443.2004 |
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