Disruption of the SH2-B Gene Causes Age-Dependent Insulin Resistance and Glucose Intolerance

Insulin regulates glucose homeostasis by binding and activating the insulin receptor, and defects in insulin responses (insulin resistance) induce type 2 diabetes. SH2-B, an Src homology 2 (SH2) and pleckstrin homology domain-containing adaptor protein, binds via its SH2 domain to insulin receptor i...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Main Authors: Duan, Chaojun, Yang, Hongyan, White, Morris F., Rui, Liangyou
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2004
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC506995/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15314154/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.17.7435-7443.2004
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