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Disruption of the SH2-B Gene Causes Age-Dependent Insulin Resistance and Glucose Intolerance
Insulin regulates glucose homeostasis by binding and activating the insulin receptor, and defects in insulin responses (insulin resistance) induce type 2 diabetes. SH2-B, an Src homology 2 (SH2) and pleckstrin homology domain-containing adaptor protein, binds via its SH2 domain to insulin receptor i...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC506995/ https://ncbi.nlm.nih.gov/pubmed/15314154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.17.7435-7443.2004 |
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