Effects of early-life exposure to THIP on phenotype development in a mouse model of Rett syndrome

BACKGROUND: Rett syndrome (RTT) is a neurodevelopmental disorder caused mostly by disruptions in the MECP2 gene. MECP2-null mice show imbalances in neuronal excitability and synaptic communications. Several previous studies indicate that augmenting synaptic GABA receptors (GABA(A)Rs) can alleviate R...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Neurodev Disord
Auteurs principaux: Zhong, Weiwei, Johnson, Christopher Mychal, Wu, Yang, Cui, Ningren, Xing, Hao, Zhang, Shuang, Jiang, Chun
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069883/
https://ncbi.nlm.nih.gov/pubmed/27777634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s11689-016-9169-2
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