A Randomized Phase 1 Dose Escalation Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Trabodenoson in Healthy Adult Volunteers

Purpose: To investigate the safety, tolerability, and pharmacokinetics of trabodenoson, a highly selective adenosine mimetic targeting the adenosine A(1) receptor. Methods: In Part 1, 60 healthy adult volunteers were randomized to 14 days of twice-daily topical monocular application of placebo or tr...

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Detalhes bibliográficos
Publicado no:J Ocul Pharmacol Ther
Main Authors: Laties, Alan, Rich, Cadmus C., Stoltz, Randall, Humbert, Vernon, Brickman, Chaim, McVicar, William, Baumgartner, Rudolf A.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069726/
https://ncbi.nlm.nih.gov/pubmed/27046445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jop.2015.0147
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