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Pore formation by GSDMD is the effector mechanism of pyroptosis

Pyroptosis is a unique, pro‐inflammatory form of lytic cell death that is initiated by the activation of inflammatory caspases. The caspase substrate gasdermin D (GSDMD) plays a critical function in pyroptosis, yet the precise mode of action of this molecule in cell death execution remained unclear....

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Shranjeno v:
Bibliografske podrobnosti
izdano v:EMBO J
Main Authors: Gaidt, Moritz M, Hornung, Veit
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069554/
https://ncbi.nlm.nih.gov/pubmed/27572465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695415
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