Glycan-Controlled Epitopes of Prion Protein Include a Major Determinant of Susceptibility to Sheep Scrapie

A key feature of prion encephalopathies is the accumulation of a misfolded form of the host glycoprotein PrP. Cell-free and cell culture studies have shown that the efficiency of conversion of PrP into the disease-associated form is influenced by its amino acid sequence and also by its carbohydrate...

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Bibliografiska uppgifter
Huvudupphovsmän: Moudjou, Mohammed, Treguer, Eric, Rezaei, Human, Sabuncu, Elifsu, Neuendorf, Erdi, Groschup, Martin H., Grosclaude, Jeanne, Laude, Hubert
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2004
Ämnen:
Pathogenesis and Immunity
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC506947/
https://ncbi.nlm.nih.gov/pubmed/15308721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.17.9270-9276.2004
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