Glycan-Controlled Epitopes of Prion Protein Include a Major Determinant of Susceptibility to Sheep Scrapie

A key feature of prion encephalopathies is the accumulation of a misfolded form of the host glycoprotein PrP. Cell-free and cell culture studies have shown that the efficiency of conversion of PrP into the disease-associated form is influenced by its amino acid sequence and also by its carbohydrate...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Moudjou, Mohammed, Treguer, Eric, Rezaei, Human, Sabuncu, Elifsu, Neuendorf, Erdi, Groschup, Martin H., Grosclaude, Jeanne, Laude, Hubert
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2004
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC506947/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15308721/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.17.9270-9276.2004
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