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Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism
Macrophage dysfunction in obesity and diabetes is associated with persistent inflammation and poor wound healing responses. Relevant to these phenotypes, we have previously shown that macrophage activation in a high-fat environment results in cell death via a mechanism that involves lysosome damage....
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| Publicado no: | J Leukoc Biol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Leukocyte Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5069097/ https://ncbi.nlm.nih.gov/pubmed/27312848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A1015-463R |
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