Novel targets for Huntington’s disease in an mTOR-independent autophagy pathway

Autophagy is a major clearance route for intracellular aggregate-prone proteins causing diseases like Huntington’s disease. Autophagy induction with the mTOR inhibitor, rapamycin, accelerates clearance of these toxic substrates. As rapamycin has non-trivial side effects, we screened FDA-approved dru...

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Détails bibliographiques
Auteurs principaux: Williams, Andrea, Sarkar, Sovan, Cuddon, Paul, Ttofi, Evangelia K., Saiki, Shinji, Siddiqi, Farah H., Jahreiss, Luca, Fleming, Angeleen, Pask, Dean, Goldsmith, Paul, O’Kane, Cahir J., Floto, R. Andres, Rubinsztein, David C.
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635566/
https://ncbi.nlm.nih.gov/pubmed/18391949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.79
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