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Rab5 modulates mutant huntingtin aggregation/toxicity in cell and fly models via macroautophagy
Huntington's disease (HD) is caused by a polyglutamine expansion mutation in huntingtin that makes the protein toxic and aggregate-prone. The subcellular localisation of huntingtin and many of its interactors suggest a role in endocytosis, and recently it has been shown that huntingtin interact...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2635563/ https://ncbi.nlm.nih.gov/pubmed/18430781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.025726 |
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