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Rab5 modulates mutant huntingtin aggregation/toxicity in cell and fly models via macroautophagy

Huntington's disease (HD) is caused by a polyglutamine expansion mutation in huntingtin that makes the protein toxic and aggregate-prone. The subcellular localisation of huntingtin and many of its interactors suggest a role in endocytosis, and recently it has been shown that huntingtin interact...

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Bibliografiske detaljer
Main Authors: Ravikumar, Brinda, Imarisio, Sara, Sarkar, Sovan, O'Kane, Cahir J, Rubinsztein, David C
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635563/
https://ncbi.nlm.nih.gov/pubmed/18430781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.025726
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