alpha-synuclein overexpression promotes aggregation of mutant huntingtin.

Protein aggregates are a neuropathological feature of Huntington's disease and Parkinson's disease. Mutant huntingtin exon 1 with 72 CAG repeats fused to enhanced green fluorescent protein (EGFP) forms hyperfluorescent inclusions in PC12 cells. Inclusion formation is enhanced in cells co-t...

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Main Authors: Furlong, R A, Narain, Y, Rankin, J, Wyttenbach, A, Rubinsztein, D C
Formato: Artigo
Idioma:Inglês
Publicado: 2000
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220887/
https://ncbi.nlm.nih.gov/pubmed/10698681
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