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Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro

Major neuropsychiatric disorders are genetically complex but share overlapping etiology. Mice mutant for rare, highly penetrant risk variants can be useful in dissecting the molecular mechanisms involved. The gene disrupted in schizophrenia 1 (DISC1) has been associated with increased risk for neuro...

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Detalhes bibliográficos
Publicado no:Transl Psychiatry
Main Authors: Tropea, D, Molinos, I, Petit, E, Bellini, S, Nagakura, I, O'Tuathaigh, C, Schorova, L, Mitchell, K J, Waddington, J, Sur, M, Gill, M, Corvin, A P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068880/
https://ncbi.nlm.nih.gov/pubmed/26756905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2015.206
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