Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1

Few studies have addressed likely gene × gene (ie, epistatic) interactions in mediating risk for schizophrenia. Using a preclinical genetic approach, we investigated whether simultaneous disruption of the risk factors Neuregulin-1 (NRG1) and Disrupted-in-schizophrenia 1 (DISC1) would produce a disea...

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Detalhes bibliográficos
Publicado no:Schizophr Bull
Principais autores: O’Tuathaigh, Colm M. P., Fumagalli, Fabio, Desbonnet, Lieve, Perez-Branguli, Francesc, Moloney, Gerard, Loftus, Samim, O’Leary, Claire, Petit, Emilie, Cox, Rachel, Tighe, Orna, Clarke, Gerard, Lai, Donna, Harvey, Richard P., Cryan, John F., Mitchell, Kevin J., Dinan, Timothy G., Riva, Marco A., Waddington, John L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216856/
https://ncbi.nlm.nih.gov/pubmed/27613806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sbw120
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