A Synthetic Dosage Lethal Genetic Interaction Between CKS1B and PLK1 Is Conserved in Yeast and Human Cancer Cells

The CKS1B gene located on chromosome 1q21 is frequently amplified in breast, lung, and liver cancers. CKS1B codes for a conserved regulatory subunit of cyclin–CDK complexes that function at multiple stages of cell cycle progression. We used a high throughput screening protocol to mimic cancer-relate...

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Vydáno v:Genetics
Hlavní autoři: Reid, Robert J. D., Du, Xing, Sunjevaric, Ivana, Rayannavar, Vinayak, Dittmar, John, Bryant, Eric, Maurer, Matthew, Rothstein, Rodney
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2016
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Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068864/
https://ncbi.nlm.nih.gov/pubmed/27558135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.190231
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