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Identification of synthetic lethality of PLK1 inhibition and microtubule-destabilizing drugs
Polo-like kinase 1 (PLK1) is frequently overexpressed in cancer, which correlates with poor prognosis. Therefore, we investigated PLK1 as therapeutic target using rhabdomyosarcoma (RMS) as a model. Here, we identify a novel synthetic lethal interaction of PLK1 inhibitors and microtubule-destabilizin...
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| 出版年: | Cell Death Differ |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2015
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4816114/ https://ncbi.nlm.nih.gov/pubmed/26024389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.59 |
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