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Identification of synthetic lethality of PLK1 inhibition and microtubule-destabilizing drugs

Polo-like kinase 1 (PLK1) is frequently overexpressed in cancer, which correlates with poor prognosis. Therefore, we investigated PLK1 as therapeutic target using rhabdomyosarcoma (RMS) as a model. Here, we identify a novel synthetic lethal interaction of PLK1 inhibitors and microtubule-destabilizin...

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書誌詳細
出版年:Cell Death Differ
主要な著者: Hugle, M, Belz, K, Fulda, S
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816114/
https://ncbi.nlm.nih.gov/pubmed/26024389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.59
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