Near-Atomic Resolution Structure of a Highly Neutralizing Fab Bound to Canine Parvovirus

Canine parvovirus (CPV) is a highly contagious pathogen that causes severe disease in dogs and wildlife. Previously, a panel of neutralizing monoclonal antibodies (MAb) raised against CPV was characterized. An antibody fragment (Fab) of MAb E was found to neutralize the virus at low molar ratios. Us...

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Bibliographic Details
Published in:J Virol
Main Authors: Organtini, Lindsey J., Lee, Hyunwook, Iketani, Sho, Huang, Kai, Ashley, Robert E., Makhov, Alexander M., Conway, James F., Parrish, Colin R., Hafenstein, Susan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068525/
https://ncbi.nlm.nih.gov/pubmed/27535057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01112-16
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