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SARM1-specific motifs in the TIR domain enable NAD(+) loss and regulate injury-induced SARM1 activation
Axon injury in response to trauma or disease stimulates a self-destruction program that promotes the localized clearance of damaged axon segments. Sterile alpha and Toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) is an evolutionarily conserved executioner of this degeneration casc...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5068253/ https://ncbi.nlm.nih.gov/pubmed/27671644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601506113 |
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