Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium

BACKGROUND: In acutely injured lungs, massively recruited polymorphonuclear neutrophils (PMNs) secrete abnormally neutrophil elastase (NE). Active NE creates a localized proteolytic environment where various host molecules are degraded leading to impairment of tissue homeostasis. Among the hallmarks...

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Détails bibliographiques
Publié dans:Respir Res
Auteurs principaux: Boxio, Rachel, Wartelle, Julien, Nawrocki-Raby, Béatrice, Lagrange, Brice, Malleret, Laurette, Hirche, Timothee, Taggart, Clifford, Pacheco, Yves, Devouassoux, Gilles, Bentaher, Abderrazzaq
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067913/
https://ncbi.nlm.nih.gov/pubmed/27751187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-016-0449-x
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