Epigenetic regulation of human DCLK-1 gene during colon-carcinogenesis: clinical and mechanistic implications

Colorectal carcinogenesis is a multi-step process. While ~25% of colorectal cancers (CRCs) arise in patients with a family history (genetic predisposition), ~75% of CRCs are due to age-associated accumulation of epigenetic alterations which can result in the suppression of key tumor suppressor genes...

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Bibliografiske detaljer
Udgivet i:Stem Cell Investig
Main Authors: Singh, Pomila, O’Connell, Malaney, Shubhashish, Sarkar
Format: Artigo
Sprog:Inglês
Udgivet: AME Publishing Company 2016
Fag:
Perspective
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067362/
https://ncbi.nlm.nih.gov/pubmed/27777940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/sci.2016.09.07
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