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Oxazin-5-Ones as a Novel Class of Penicillin Binding Protein Inhibitors: Design, Synthesis and Structure Activity Relationship

Penicillin binding proteins (PBPs) are normal constituents of bacterial which are absent in mammalian cells. The theoretical binding modes of known oxazin-5-ones toward the protein were used as a guide to synthesis new inhibitors. Structural studies of protein-ligand complexes revealed that conforma...

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Opis bibliograficzny
Wydane w:PLoS One
Główni autorzy: Onoabedje, Efeturi Abraham, Ibezim, Akachukwu, Okafor, Sunday Nwankwor, Onoabedje, Ufuoma Shalom, Okoro, Uchechukwu Chris
Format: Artigo
Język:Inglês
Wydane: Public Library of Science 2016
Hasła przedmiotowe:
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066960/
https://ncbi.nlm.nih.gov/pubmed/27749913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163467
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