Oxazin-5-Ones as a Novel Class of Penicillin Binding Protein Inhibitors: Design, Synthesis and Structure Activity Relationship

Penicillin binding proteins (PBPs) are normal constituents of bacterial which are absent in mammalian cells. The theoretical binding modes of known oxazin-5-ones toward the protein were used as a guide to synthesis new inhibitors. Structural studies of protein-ligand complexes revealed that conforma...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Onoabedje, Efeturi Abraham, Ibezim, Akachukwu, Okafor, Sunday Nwankwor, Onoabedje, Ufuoma Shalom, Okoro, Uchechukwu Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066960/
https://ncbi.nlm.nih.gov/pubmed/27749913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163467
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados