Amorphous silica nanoparticles trigger vascular endothelial cell injury through apoptosis and autophagy via reactive oxygen species-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling

Environmental exposure to silica nanoparticles (SiNPs) is inevitable due to their widespread application in industrial, commercial, and biomedical fields. In recent years, most investigators focus on the evaluation of cardiovascular effects of SiNPs in vivo and in vitro. Endothelial injury and dysfu...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Guo, Caixia, Yang, Man, Jing, Li, Wang, Ji, Yu, Yang, Li, Yang, Duan, Junchao, Zhou, Xianqing, Li, Yanbo, Sun, Zhiwei
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066858/
https://ncbi.nlm.nih.gov/pubmed/27785026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S112030
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