Huperzine A Provides Robust and Sustained Protection against Induced Seizures in Scn1a Mutant Mice

De novo loss-of-function mutations in the voltage-gated sodium channel (VGSC) SCN1A (encoding Na(v)1.1) are the main cause of Dravet syndrome (DS), a catastrophic early-life encephalopathy associated with prolonged and recurrent early-life febrile seizures (FSs), refractory afebrile epilepsy, cognit...

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Udgivet i:Front Pharmacol
Main Authors: Wong, Jennifer C., Dutton, Stacey B. B., Collins, Stephen D., Schachter, Steven, Escayg, Andrew
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065986/
https://ncbi.nlm.nih.gov/pubmed/27799911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00357
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