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A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β

The design and synthesis of dual aromatase inhibitors/selective estrogen receptor modulators (AI/SERMs) is an attractive strategy for the discovery of new breast cancer therapeutic agents. Previous efforts led to the preparation of norendoxifen (4) derivatives with dual aromatase inhibitory activity...

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Dettagli Bibliografici
Pubblicato in:Bioorg Med Chem
Autori principali: Zhao, Li-Ming, Jin, Hai-Shan, Liu, Jinzhong, Skaar, Todd C., Ipe, Joseph, Lv, Wei, Flockhart, David A., Cushman, Mark
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065788/
https://ncbi.nlm.nih.gov/pubmed/27647367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.08.064
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