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A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β
The design and synthesis of dual aromatase inhibitors/selective estrogen receptor modulators (AI/SERMs) is an attractive strategy for the discovery of new breast cancer therapeutic agents. Previous efforts led to the preparation of norendoxifen (4) derivatives with dual aromatase inhibitory activity...
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| Publicat a: | Bioorg Med Chem |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5065788/ https://ncbi.nlm.nih.gov/pubmed/27647367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.08.064 |
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