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Augmented HR Repair Mediates Acquired-temozolomide Resistance in Glioblastoma

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults, and is universally fatal. The DNA alkylating agent temzolomide (TMZ) is part of the standard-of-care for GBM. However, these tumors eventually develop therapy-driven resistance and inevitably recur. While...

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Foilsithe in:Mol Cancer Res
Main Authors: Gil del Alcazar, Carlos Rodrigo, Todorova, Pavlina Krasimirova, Habib, Amyn A., Mukherjee, Bipasha, Burma, Sandeep
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065752/
https://ncbi.nlm.nih.gov/pubmed/27358111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0125
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