Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury

WNT/β-catenin signalling is crucial for intestinal homoeostasis. The intestinal epithelium and stroma are the major source of WNT ligands but their origin and role in intestinal stem cell (ISC) and epithelial repair remains unknown. Macrophages are a major constituent of the intestinal stroma. Here,...

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Publicat a:Nat Commun
Autors principals: Saha, Subhrajit, Aranda, Evelyn, Hayakawa, Yoku, Bhanja, Payel, Atay, Safinur, Brodin, N Patrik, Li, Jiufeng, Asfaha, Samuel, Liu, Laibin, Tailor, Yagnesh, Zhang, Jinghang, Godwin, Andrew K., Tome, Wolfgang A., Wang, Timothy C., Guha, Chandan, Pollard, Jeffrey W.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065628/
https://ncbi.nlm.nih.gov/pubmed/27734833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13096
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