Efavirenz inhibits the human ether-a-go-go related current (hERG) and induces QT interval prolongation in CYP2B6*6*6 allele carriers

BACKGROUND: Efavirenz (EFV) has been associated with torsade de pointes despite marginal QT interval lengthening. Since EFV is metabolized by the cytochrome P450 (CYP) 2B6 enzyme, we hypothesized that EFV would lengthen the rate-corrected QT (QTcF) interval in carriers of the CYP2B6*6 decreased func...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Cardiovasc Electrophysiol
Hlavní autoři: Abdelhady, Ahmed M., Shugg, Tyler, Thong, Nancy, Li Lu, Jessica Bo, Kreutz, Yvonne, Jaynes, Heather A., Robarge, Jason D., Tisdale, James E., Desta, Zeruesenay, Overholser, Brian R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065384/
https://ncbi.nlm.nih.gov/pubmed/27333947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jce.13032
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky