Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification

Primordial germ cell (PGC) development is characterized by global epigenetic remodeling, which resets genomic potential and establishes an epigenetic ground state. Here we recapitulate PGC specification in vitro from naive embryonic stem cells and characterize the early events of epigenetic reprogra...

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Udgivet i:Dev Cell
Main Authors: von Meyenn, Ferdinand, Berrens, Rebecca V., Andrews, Simon, Santos, Fátima, Collier, Amanda J., Krueger, Felix, Osorno, Rodrigo, Dean, Wendy, Rugg-Gunn, Peter J., Reik, Wolf
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064768/
https://ncbi.nlm.nih.gov/pubmed/27728778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2016.09.015
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