Sintokamide A Is a Novel Antagonist of Androgen Receptor That Uniquely Binds Activation Function-1 in Its Amino-terminal Domain

Androgen receptor (AR) is a validated drug target for all stages of prostate cancer including metastatic castration-resistant prostate cancer (CRPC). All current hormone therapies for CRPC target the C-terminal ligand-binding domain of AR and ultimately all fail with resumed AR transcriptional activ...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Banuelos, Carmen A., Tavakoli, Iran, Tien, Amy H., Caley, Daniel P., Mawji, Nasrin R., Li, Zhenzhen, Wang, Jun, Yang, Yu Chi, Imamura, Yusuke, Yan, Luping, Wen, Jian Guo, Andersen, Raymond J., Sadar, Marianne D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Gene Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064002/
https://ncbi.nlm.nih.gov/pubmed/27576691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.734475
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