An imaging agent to detect androgen receptor and its active splice variants in prostate cancer

Constitutively active splice variants of androgen receptor (AR-Vs) lacking ligand-binding domain (LBD) are a mechanism of resistance to androgen receptor LBD–targeted (AR LBD–targeted) therapies for metastatic castration-resistant prostate cancer (CRPC). There is a strong unmet clinical need to iden...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Imamura, Yusuke, Tien, Amy H., Pan, Jinhe, Leung, Jacky K., Banuelos, Carmen A., Jian, Kunzhong, Wang, Jun, Mawji, Nasrin R., Fernandez, Javier Garcia, Lin, Kuo-Shyan, Andersen, Raymond J., Sadar, Marianne D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
Schlagworte:
Technical Advance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980083/
https://ncbi.nlm.nih.gov/pubmed/27525313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.87850
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